Document Detail


Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone.
MedLine Citation:
PMID:  7723844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kaposi's sarcoma (KS) occurs more often in men than in women and HIV-1-associated KS has a high occurrence in homosexual men (over 30%). Most cultures of KS tumours yield cells with properties of hyperplastic (not malignant) endothelial cells under the control of several cytokines. The role of HIV-1 may be in promoting high levels of some cytokines and providing stimulation to angiogenesis by the HIV-1 Tat protein, which synergizes with basic fibroblast growth factor in promoting these effects. Here we describe an immortalized AIDS-KS cell line (KS Y-1) and show that these cells produce malignant metastatic tumours in nude mice and are killed in vitro and in vivo (apparently by apoptosis) by a pregnancy hormone, the beta-chain of human chorionic gonadotropin. Similarly, chorionic gonadotropin kills KS SLK, cells from another neoplastic cell line (established from a non-HIV-associated KS), as well as the hyperplastic KS cells from clinical specimens grown in short-term culture, but does not kill normal endothelial cells. These results provide evidence that KS can evolve into a malignancy and have implications for the hormonal treatment of this tumour.
Authors:
Y Lunardi-Iskandar; J L Bryant; R A Zeman; V H Lam; F Samaniego; J M Besnier; P Hermans; A R Thierry; P Gill; R C Gallo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  375     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  IM; X    
Affiliation:
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications
Adult
Animals
Apoptosis
Chorionic Gonadotropin / therapeutic use*
Female
Humans
Immunocompromised Host
Male
Mice
Mice, Nude
Pregnancy
Sarcoma, Kaposi / complications,  immunology,  secondary,  therapy*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin
Comments/Corrections
Comment In:
Nature. 1995 Sep 7;377(6544):21; author reply 22   [PMID:  7659154 ]
Nature. 1995 Sep 7;377(6544):21-2   [PMID:  7659155 ]
Erratum In:
Nature 1995 Aug 3;376(6539):447

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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