Document Detail


Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer.
MedLine Citation:
PMID:  23199207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: This work aimed to determine if the treatment outcomes of bladder cancer could be improved by targeting micelles that are decorated with bladder cancer-specific ligands on the surface and loaded with the chemotherapeutic drug paclitaxel.
MATERIALS & METHODS: Targeting efficacy and specificity was determined with cell lines. An in vivo targeting and anti-tumor efficacy study was conducted in mice carrying patient-derived xenografts. Results &
DISCUSSION: Targeting micelles were more efficient than nontargeting micelles in delivering the drug load into bladder cancer cells both in vitro and in vivo (p < 0.05). The micelle formulation of paclitaxel was less toxic than free paclitaxel in Cremophor(®) (Sigma, MO, USA) and allowed administration of three-times the maximum tolerated dose without increasing the toxicity. Targeting micelles were more effective than the nontargeting micelles in controlling cancer growth (p = 0.0002) and prolonging overall survival (p = 0.002).
CONCLUSION: Targeting micelles loaded with paclitaxel offer strong potential for clinical applications in treating bladder cancer.
Authors:
Tzu-Yin Lin; Yuan-Pei Li; Hongyong Zhang; Juntao Luo; Neal Goodwin; Tingjuan Gao; Ralph de Vere White; Kit S Lam; Chong-Xian Pan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-12-02
Journal Detail:
Title:  Nanomedicine (London, England)     Volume:  8     ISSN:  1748-6963     ISO Abbreviation:  Nanomedicine (Lond)     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-06     Completed Date:  2014-05-06     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101278111     Medline TA:  Nanomedicine (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1239-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Delivery Systems / adverse effects*
Humans
Maximum Tolerated Dose
Mice
Micelles
Paclitaxel / administration & dosage*,  chemistry
Treatment Outcome
Urinary Bladder Neoplasms / drug therapy*,  pathology
Grant Support
ID/Acronym/Agency:
P41 RR013461/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Micelles; 33069-62-4/Paclitaxel
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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