Document Detail

Tumor suppressor gene allelic loss profiles of the variants of papillary thyroid carcinoma.
MedLine Citation:
PMID:  15163008     Owner:  NLM     Status:  MEDLINE    
Papillary thyroid carcinoma (PTCa) is a relatively common, indolent tumor that usually has an excellent prognosis. While the diagnosis of conventional PTCa is relatively straightforward, encapsulated tumors with follicular growth pattern and unusual or incomplete cytologic features of papillary carcinoma can be diagnostically challenging. Encapsulated, noninvasive tumors are particularly controversial as the differential diagnosis includes a nonneoplastic nodule, a benign follicular adenoma, and papillary carcinoma. In this study, we performed molecular genotyping to identify loss of heterozygosity of tumor suppressor genes in conventional PTCa and in several different morphologic variants, including follicular variant, tall cell variant, and oncocytic variant. Our data demonstrate that conventional PTCas have the lowest frequency of allelic loss (7%), as compared with follicular, oncocytic, and tall cell variants (19%, 34%, and 20%, respectively). Frequency of allelic loss increased with increasing size of the tumors, but did not correlate with age, gender, extrathyroidal extension, or lymph node metastases. Though it is unlikely that these results will enable the distinction between different variants of papillary carcinoma, the finding of significant rates ofallelic loss in the variants of PTCa provides additional evidence of malignancy and may be useful in distinguishing encapsulated tumors from nonneoplastic or benign nodules.
Jennifer L Hunt; Melissa Fowler; Deren Lomago; Laura Niehouse; Eizaburo Sasatomi; Patricia Swalsky; Sydney Finkelstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic molecular pathology : the American journal of surgical pathology, part B     Volume:  13     ISSN:  1052-9551     ISO Abbreviation:  Diagn. Mol. Pathol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-27     Completed Date:  2004-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204924     Medline TA:  Diagn Mol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA 15213, USA.
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MeSH Terms
Carcinoma, Papillary / diagnosis*,  genetics,  pathology
Genes, Tumor Suppressor*
Loss of Heterozygosity / genetics*
Middle Aged
Polymerase Chain Reaction
Retrospective Studies
Thyroid Neoplasms / diagnosis*,  genetics,  pathology
Tumor Markers, Biological / genetics
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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