Document Detail


Tumor-suppressive effects of 1, 25-dihydroxyvitamin D3 in gastric cancer cells.
MedLine Citation:
PMID:  23298900     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUNDS/AIMS: It has been previously demonstrated that vitamin D acts as a prognostic indicator of gastric cancer and may be correlated with the incidence risk of gastric cancer. However, the effect of 1,25-dihydroxyvitamin D3 on the apoptosis of human gastric cancer cells is unclear. The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 induced the cellular apoptosis of BGC-823 gastric cancer cells and to determine the potential mechanism of action.
METHODOLOGY: We demonstrate that 1,25-dihydroxyvitamin D3 induced the apoptosis of gastric cancer cells via the processing of PARP and cleavage of caspase 3. Additionally, an increase in BAX expression and a decrease in ERK1/2 and AKT phosphorylation were associated with 1,25-dihydroxyvitamin D3-induced apoptosis. The mRNA expression levels of VDR, CYP24A1, and p21 were increased significantly following 1,25-dihydroxyvitamin D3 treatment.
CONCLUSIONS: These findings suggest that 1,25-dihydroxyvitamin D3 exerts tumor-suppressive effects on BGC-823 human gastric cancer cells.
Authors:
Anyu Bao; Yan Li; Yongqing Tong; Hongyun Zheng; Wei Wu; Chuandong Wei
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-09
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  60     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-09-26     Completed Date:  2013-12-17     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  943-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / drug effects*
Blotting, Western
Cyclin-Dependent Kinase Inhibitor p21 / drug effects
Humans
MAP Kinase Signaling System / drug effects
Phosphorylation
Proto-Oncogene Proteins c-akt / drug effects
Receptors, Calcitriol / drug effects
Reverse Transcriptase Polymerase Chain Reaction
Steroid Hydroxylases / drug effects
Stomach Neoplasms / drug therapy*
Tumor Cells, Cultured / drug effects
Vitamin D / analogs & derivatives*,  pharmacology
bcl-2-Associated X Protein / drug effects
Chemical
Reg. No./Substance:
0/Cyclin-Dependent Kinase Inhibitor p21; 0/Receptors, Calcitriol; 0/VDR protein, human; 0/bcl-2-Associated X Protein; 0/dihydroxy-vitamin D3; 1406-16-2/Vitamin D; EC 1.14.-/Steroid Hydroxylases; EC 1.14.13.126/vitamin D 24-hydroxylase; EC 2.7.11.1/Proto-Oncogene Proteins c-akt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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