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Tumor spectrum in lynch syndrome, DNA mismatch repair system and endogenous carcinogens.
MedLine Citation:
PMID:  22275225     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inactivation of Mismatch Repair genes in Lynch Syndrome, caused by inherited mutations, decreases the ability to repair DNA errors throughout life. This deficit may allow the development of any tumor type. Nevertheless, the Syndrome develops a specific tumor spectrum associated with the disease. We think that such spectrum of tumors would be related to the action of certain endogenous carcinogens such as bile acids and estrogens that aggravate the inherited defect. J. Surg. Oncol © 2012 Wiley Periodicals, Inc.
Authors:
Vicente Medina-Arana; Luciano Delgado; Alberto Bravo; Juana Martín; Antonia M Fernández-Peralta; Juan J González-Aguilera
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-24
Journal Detail:
Title:  Journal of surgical oncology     Volume:  -     ISSN:  1096-9098     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Servicio de Cirugía General y Digestiva, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
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