Document Detail

Tumor-specific cytotoxicity and type of cell death induced by peplomycin in oral squamous cell carcinoma cell lines.
MedLine Citation:
PMID:  18751395     Owner:  NLM     Status:  MEDLINE    
The antitumor antibiotic peplomycin showed higher cytostatic antiproliferative effect on five cultured human oral squamous cell carcinoma (OSCC) cell lines (HSC-2, HSC-3, HSC-4, Ca9-22 and NA), as compared with three human oral normal cells (gingival fibroblast HGF, pulp cell HPC and periodontal ligament fibroblast HPLF). Although the antiproliferative activity of peplomycin declined with increasing cell density, peplomycin showed tumor-specific cytotoxicity at any cell density. The five OSCC cell lines showed considerable differences in sensitivity against peplomycin; the HSC-2 cells were the most sensitive, followed by the NA, HSC-3, Ca9-22 and HSC-4 cells. Peplomycin did not induce internucleosomal DNA fragmentation in any of the five OSCC cell lines, and only slightly modified caspase-3, -8 and -9 activities in the HSC-2, Ca9-22 and NA cell lines. Electron microscopy revealed that peplomycin induced the vacuolation of mitochondria accompanying electron lucent matrices lacking cristae and the enlargement of the endoplasmic reticulum in the HSC-2 cells. These data suggest that the anti-proliferative effect of peplomycin is time-dependent, and therefore prolonged treatment with peplomycin in combination with cytotoxic chemotherapeutic agents may induce greater cytotoxic action.
Yu Liu; Hiroshi Sakagami; Osamu Amano; Hirotaka Kikuchi; Yukio Nakamura; Mariko Ishihara; Yumiko Kanda; Shiro Kunii; Wei Zhang; Guangyan Yu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  28     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-08-28     Completed Date:  2008-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2197-204     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
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MeSH Terms
Antibiotics, Antineoplastic / pharmacology*
Carcinoma, Squamous Cell / drug therapy*,  pathology*,  ultrastructure
Cell Death / drug effects
Cell Line, Tumor
Fibroblasts / cytology,  drug effects
Microscopy, Electron
Mouth Neoplasms / drug therapy*,  pathology*,  ultrastructure
Peplomycin / pharmacology*
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 68247-85-8/Peplomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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