Document Detail


Tumor response assessments with diffusion and perfusion MRI.
MedLine Citation:
PMID:  22434697     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
There is an increasing awareness that the evaluation of tumor response to oncologic treatments based solely on anatomic imaging assessments face many limitations, particularly in this era of novel biologic targeted therapies. Functional imaging techniques such as diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) have the ability to depict important tumor biologic features and are able to predict therapy response based on assessments of cellularity and tumor vascularity, which often precede morphologic alterations. In this article we focus on DW-MRI and DCE-MRI as response parameters addressing the technologies involved, quantification methods, and validation for each technique and their current role in imaging response to conventional and novel therapies. We also discuss the challenges that lie ahead in the deployment of these imaging methods into the clinical environment. J. Magn. Reson. Imaging 2012;35:745-763. © 2011 Wiley Periodicals, Inc.
Authors:
Sonia P Li; Anwar R Padhani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  35     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  745-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Academic Oncology Unit, Mount Vernon Cancer Centre, Northwood, Middlesex, UK.
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