| Tumor promoting functions of TGF-β in CML-initiating cells. | |
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MedLine Citation:
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PMID: 22989931 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Recent data have shown that transforming growth factor-β (TGF-β) plays bi-directional roles in the maintenance of cancer stem cells in a cell-type and context-dependent manner. Zhu and colleagues studied the functions of TGF-β in hemangioblasts from patients with chronic myeloid leukemia (CML), which displayed properties of leukemia-initiating cells (Zhu et al. (2011) J. Biochem. 149, 405-414). They have shown that the BCR/ABL oncoprotein induced the production of TGF-β in the CML hemangioblasts, and that TGF-β activated the PI3K-Akt-NF-κB pathway in these cells. Activation of this pathway enhanced the production of matrix metalloproteinase-9, leading to increased synthesis of soluble Kit ligand and ICAM-1. TGF-β is known to maintain the CML-initiating cells through the Akt-FoxO pathway. Together, these findings suggest that TGF-β may exhibit multiple functions in progression of CML through acting on leukemia-initiating cells. |
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Authors:
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Kohei Miyazono |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-17 |
Journal Detail:
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Title: Journal of biochemistry Volume: - ISSN: 1756-2651 ISO Abbreviation: J. Biochem. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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