Document Detail

Tumor pO2 assessments in human xenograft tumors measured by EPR oximetry: location of paramagnetic materials.
MedLine Citation:
PMID:  14562718     Owner:  NLM     Status:  MEDLINE    
Radioantibody immunotherapy (RAIT) is a promising treatment modality but the effectiveness of this targeted low dose radiation varies from tumor to tumor. Since RAIT is an oxygen dependent treatment, baseline pO2 or growth-induced changes in the microenvironment may alter treatment response. In this pilot work we monitored tumor pO2 in untreated human xenograft tumors growing s.c. in nude mice. These data will be used to plan a study of the relationship between the effectiveness of RAIT and tumor pO2. Growth or treatment-induced changes in the microenvironment may alter the tumor pO2 and thus affect the response to therapy but may also affect location and microenvironment of the particulate oxygen sensor. We monitored tumor pO2 during growth and also examined the tumor histological structure overall and in the region of the paramagnetic material in the tumor at the time of necropsy.
Julia A O'Hara; Rosalyn D Blumenthal; Oleg Y Grinberg; Stalina Grinberg; Carmen Wilmot; David M Goldenberg; Harold M Swartz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  530     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-17     Completed Date:  2003-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-14     Citation Subset:  IM    
Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA.
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MeSH Terms
Electron Spin Resonance Spectroscopy
Neoplasm Transplantation
Neoplasms / metabolism*
Oximetry / methods*
Oxygen / metabolism*
Reg. No./Substance:

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