Document Detail


Tumor oxygen dynamics: comparison of 19F MR EPI and frequency domain NIR spectroscopy.
MedLine Citation:
PMID:  14562720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxygen plays a key role in tumor therapy and may be related to tumor development: e.g., angiogenesis and metastasis. Using noninvasive techniques to accurately measure tumor oxygenation could assist in developing novel therapies. Here, we have used the FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) approach based on hexafluorobenzene (HFB) to monitor tissue oxygen tension (pO2) of rat breast and prostate tumors and compared the results with changes in tumor vascular hemoglobin saturation (sO2) and concentration observed using a new dual wavelength homodyne near-infrared (NIR) system. The dynamic changes in pO2 and sO2 were assessed while rats were breathing various gases. NIR showed significant changes in vascular oxygenation accompanying respiratory interventions. 19F MR-EPI also showed significant changes in tissue pO2 and revealed considerable regional heterogeneity in both absolute values and rate of change accompanying interventions. Generally, changes in vascular sO2 preceded tissue pO2, particularly for smaller tumors.
Authors:
Yulin Song; Kate L Worden; Xin Jiang; Dawen Zhao; Anca Constantinescu; Hanli Liu; Ralph P Mason
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  530     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-17     Completed Date:  2003-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-36     Citation Subset:  IM    
Affiliation:
Joint Graduate Program in Biomedical Engineering, Department of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Magnetic Resonance Imaging / methods*
Male
Oxygen / metabolism*
Rats
Spectroscopy, Near-Infrared / methods*
Grant Support
ID/Acronym/Agency:
R01 CA79515/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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