Document Detail

Tumor necrosis factor receptor 1 expression and early spontaneous abortion.
MedLine Citation:
PMID:  15617704     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare tumor necrosis factor receptor 1 (TNFR1) protein expression in women with unexplained early spontaneous abortion (UESA) and normal pregnancy. METHODS: In a prospective study, 62 women with UESA and 60 with normal pregnancy were studied. Decidual membrane TNFR1 was detected by flow cytometry and immunohistochemistry, and serum soluble TNFR1 were by ELISA. Statistical analyses of resulting data employed the student's t test, the Fisher's Exact, and the nonparametric Wilcoxon test RESULTS: The percentage of membrane tumor necrosis factor receptor 1 (mTNFR1) positive decidual cells was 16.42+/-7.1 for women with UESA and 12.47+/-5.3 for women with normal pregnancy (p<0.05). The number of mTNFR1 positive cells was more in decidual stromal and vessel endothelial cells in women with UESA, and serum soluble tumor necrosis factor receptor 1 (sTNFR1) concentration was significantly higher than in women with normal pregnancy (554.56+/-126.7 pg/ml vs. 175.3+/-52.4 pg/ml; p<0.001). CONCLUSION: The overexpression of TNFR1 may contribute to the development of ESA.
X W Yu; C F Yan; H Jin; X Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  88     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-24     Completed Date:  2005-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
Center of Maternal and Child Health, First Hospital of Xi'an Jiaotong University, Xi'an, 710061 China.
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MeSH Terms
Abortion, Spontaneous / metabolism*
Decidua / metabolism*
Endothelial Cells / metabolism
Flow Cytometry
Pregnancy Trimester, First
Prospective Studies
Receptors, Tumor Necrosis Factor, Type I / metabolism*
Reg. No./Substance:
0/Receptors, Tumor Necrosis Factor, Type I

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