Document Detail


Tumor necrosis factor and interleukin-6 levels in hypertensive patients with and without left ventricular hypertrophy.
MedLine Citation:
PMID:  15823943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this prospective study was to examine the association between serum levels of TNF (tumor-necrosis factor) and IL-6 (interleukin-6) and left ventricular mass in hypertensive patients. Hypertensive patients currently receiving medical therapy were eligible. All subjects underwent echocardiography with measurements of left ventricular (LV) mass and ejection fraction (EF) and had serum levels of TNF and IL-6 measured by ELISA immunoassay. 35 subjects (20F, 15M; mean age 56.4 +/- 10.5 yrs) were studied. 19 patients (54%) had elevated LV mass. Of these patients, 6 (32%) had detectable serum TNF levels and 1 (7%) had detectable IL-6 levels, (p = NS). Hypertensive patients with elevated LV mass do not consistently exhibit elevated cytokine levels when compared to those with normal LV mass.
Authors:
David Leibowitz; David Planer; Fanny Ben-Ivgi; A Teddy Weiss; Michael Bursztyn
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  14     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  2005  
Date Detail:
Created Date:  2005-04-12     Completed Date:  2005-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Affiliation:
Coronary Care Unit and Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem. oleibo@hadassah.org.il
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MeSH Terms
Descriptor/Qualifier:
Aged
Echocardiography
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hypertension / blood,  complications*
Hypertrophy, Left Ventricular / blood*
Interleukin-6 / blood*
Male
Middle Aged
Prospective Studies
Stroke Volume
Tumor Necrosis Factor-alpha / analysis*
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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