Document Detail

Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma.
MedLine Citation:
PMID:  11756988     Owner:  NLM     Status:  MEDLINE    
To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 patients with EBV-negative GC, and 220 control subjects were enrolled. Promoter polymorphisms of tumor necrosis factor (TNF)-alpha at positions -238 and -308 and of interleukin (IL)-10 at position -1082 were determined. The frequency of the high-producer allele (-308A) in the TNF-alpha gene was significantly higher among EBV-positive GC patients compared with control subjects (23.3% vs. 12.0%, P<.05), whereas the frequency of the high-producer allele (-1082G) in the IL-10 gene was significantly higher among EBV-negative GC patients compared with control subjects (6.3% vs. 3.0%, P<.05). These data support the notion that genetic factors may modify the outcomes of infectious diseases through different TNF-alpha- or IL-10-producing capabilities.
Ming-Shiang Wu; Shih-Pei Huang; Yu-Ting Chang; Chia-Tung Shun; Ming-Chu Chang; Ming-Tsan Lin; Hsiu-Po Wang; Jaw-Town Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2001-12-14
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  185     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-9     Citation Subset:  AIM; IM    
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
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MeSH Terms
Adenocarcinoma / complications,  genetics*,  virology
China / ethnology
Epstein-Barr Virus Infections / complications,  genetics*
Gene Frequency
Interleukin-10 / genetics*
Polymorphism, Genetic
Promoter Regions, Genetic
Stomach Neoplasms / complications,  genetics*,  virology
Tumor Necrosis Factor-alpha / genetics*
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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