Document Detail


Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma.
MedLine Citation:
PMID:  11756988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 patients with EBV-negative GC, and 220 control subjects were enrolled. Promoter polymorphisms of tumor necrosis factor (TNF)-alpha at positions -238 and -308 and of interleukin (IL)-10 at position -1082 were determined. The frequency of the high-producer allele (-308A) in the TNF-alpha gene was significantly higher among EBV-positive GC patients compared with control subjects (23.3% vs. 12.0%, P<.05), whereas the frequency of the high-producer allele (-1082G) in the IL-10 gene was significantly higher among EBV-negative GC patients compared with control subjects (6.3% vs. 3.0%, P<.05). These data support the notion that genetic factors may modify the outcomes of infectious diseases through different TNF-alpha- or IL-10-producing capabilities.
Authors:
Ming-Shiang Wu; Shih-Pei Huang; Yu-Ting Chang; Chia-Tung Shun; Ming-Chu Chang; Ming-Tsan Lin; Hsiu-Po Wang; Jaw-Town Lin
Related Documents :
23831508 - Critical role for ccr2 and hmgb1 in induction of experimental endotoxic shock.
9563758 - Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tu...
9386848 - Plasma interleukin-1 beta and tumor necrosis factor concentrations in obsessive-compuls...
14500138 - Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammato...
19934378 - Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (asb-4)...
24321498 - Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and rec...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2001-12-14
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  185     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / complications,  genetics*,  virology
China / ethnology
Epstein-Barr Virus Infections / complications,  genetics*
Gene Frequency
Humans
Interleukin-10 / genetics*
Polymorphism, Genetic
Promoter Regions, Genetic
Stomach Neoplasms / complications,  genetics*,  virology
Taiwan
Tumor Necrosis Factor-alpha / genetics*
Chemical
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni.
Next Document:  Selective reactivation of human herpesvirus 6 variant a occurs in critically ill immunocompetent hos...