Document Detail

Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers.
MedLine Citation:
PMID:  16319659     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: As is well known, acute myocardial infarction presents two electrocardiogram (EKG) patterns, ST-elevation (STEMI) and no ST-elevation (NSTEMI), characterized by different coronary artery thrombotic occlusion. Growing evidence shows that inflammation plays a central role in the pathogenesis of acute myocardial infarction. Among the factors that promote inflammation and arterial thrombosis, one of the most important is the proinflammatory cytokine tumor necrosis factor-alpha. The expression of this cytokine is modulated by a polymorphism located at nucleotide -308 of tumor necrosis factor-alpha promoter gene. The objective of our study is to verify whether tumor necrosis factor-alpha -308 polymorphism is associated with risk of acute myocardial infarction (STEMI and NSTEMI) or with biochemical myocardial ischemia markers, such as troponin I, creatine kinase-MB, lactate dehydrogenase and myoglobin. METHODS: We analyzed tumor necrosis factor-alpha -308 polymorphism in a total of 603 study participants: 293 elderly patients affected by acute myocardial infarction (STEMI and NSTEMI) and 310 healthy controls. RESULTS: We found that individuals carrying the tumor necrosis factor-alpha -308 AG+AA genotypes are significantly more represented among acute myocardial infarction patients affected by STEMI than among NSTEMI patients (OR = 1.86, 95% CI 1.08-3.21, p = 0.027) and healthy controls (OR = 1.64, 95% CI 1.03-2.64, p = 0.046). Furthermore, the patients carrying tumor necrosis factor-alpha -308 AG+AA genotypes displayed significant increased levels of biochemical myocardial ischemia markers. CONCLUSIONS: Our study shows a significant association between the tumor necrosis factor-alpha -308 polymorphism and the occurrence of STEMI, and suggests that the tumor necrosis factor-alpha -308 polymorphism could play a role in the pathogenesis of cardiac ischemic damage, AA+AG genotype carrier individuals being likely to be affected by more severe ischemic damage than the rest of the population.
Roberto Antonicelli; Fabiola Olivieri; Luca Cavallone; Liana Spazzafumo; Massimiliano Bonaf?; Francesca Marchegiani; Maurizio Cardelli; Roberta Galeazzi; Simona Giovagnetti; Gian Piero Perna; Claudio Franceschi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Coronary artery disease     Volume:  16     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-01     Completed Date:  2006-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  489-93     Citation Subset:  IM    
Center of Molecular Biology, Department of Cardiology-CCU and Center of Statistics, Italian National Research Centers on Aging (I.N.R.C.A.), Ancona, Italy.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Creatine Kinase, MB Form / blood
L-Lactate Dehydrogenase / blood
Myocardial Infarction / genetics*,  physiopathology
Myocardial Ischemia / genetics*,  physiopathology
Myoglobin / blood
Polymorphism, Genetic*
Risk Factors
Troponin I / blood
Tumor Necrosis Factor-alpha / genetics*
Reg. No./Substance:
0/Biological Markers; 0/Myoglobin; 0/TNF protein, human; 0/Troponin I; 0/Tumor Necrosis Factor-alpha; EC Dehydrogenase; EC Kinase, MB Form

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