Document Detail


Tumor necrosis factor-alpha -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans.
MedLine Citation:
PMID:  15725578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine the frequency and potential relevance of the promoter polymorphisms of the tumor necrosis factor-alpha (TNF-alpha) in the severity of rheumatoid arthritis (RA) in Mexicans. HLA-DR and polymorphisms at positions -238 and -308 of TNF-alpha gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were typed for HLA-DR). We observed an increased frequency of HLA-DR4 in severe RA compared to healthy controls (pC=0.02, OR=2.33). TNF polymorphism analysis showed a significant increased frequency of TNF -238 GG genotype in the whole group of RA patients when compared to healthy controls (pC=0.007, OR=4.71). When the analyses were carried out separately in severe and non-severe RA patients, the increased frequency of -238 GG genotype only was observed in patients with non-severe forms of the disease. Analysis of -308 polymorphism showed increased frequency of -308 T2 (A) allele in severe RA when compared to non-severe disease (pC=0.011, OR=3.29) and to healthy controls (pC=0.002, OR=3.97). The data demonstrate that -308 T2 (A) allele is associated with susceptibility to develop severe RA in Mexicans. This association could be independent from HLA-DR alleles and might be used as a prognostic marker for severe RA.
Authors:
Alma Angelica Rodríguez-Carreón; Joaquín Zúñiga; Guadalupe Hernández-Pacheco; José Manuel Rodríguez-Pérez; Nonanzit Pérez-Hernández; Jose Vicente Montes de Oca; Mario H Cardiel; Julio Granados; Gilberto Vargas-Alarcón
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autoimmunity     Volume:  24     ISSN:  0896-8411     ISO Abbreviation:  J. Autoimmun.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-23     Completed Date:  2005-08-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8812164     Medline TA:  J Autoimmun     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Affiliation:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Arthritis, Rheumatoid / genetics*,  pathology*
Female
Genotype
HLA Antigens / genetics*
Humans
Male
Mexican Americans / genetics*
Middle Aged
Phenotype
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics*
Tumor Necrosis Factor-alpha / genetics*
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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