| Tumor microenvironment and drug resistance in hematologic malignancies. | |
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MedLine Citation:
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PMID: 16920238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing evidence supports the role of the tumor microenvironment in conferring drug resistance as a major cause of relapse and incurability of cancers. The tumor microenvironment consists of normal stromal cells, extracellular matrix, and soluble factors such as cytokines and growth factors. Tumor-tumor cell interaction, tumor-stromal cell interaction, as well as tumor-ECM interaction, all contribute to direct cell contact mediated drug resistance. In addition, soluble factors produced in the tumor microenvironment provide further signals for tumor cell growth and survival. Environment mediated-drug resistance (EM-DR) could be considered as the totality of cell adhesion mediated drug resistance (CAM-DR) and soluble factor mediated drug resistance (SM-DR) produced by the tumor-host interaction. This review focuses on the EM-DR model system and signaling pathways involved in cell survival of hematological malignancies. |
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Authors:
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Zhi-Wei Li; William S Dalton |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-08-22 |
Journal Detail:
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Title: Blood reviews Volume: 20 ISSN: 0268-960X ISO Abbreviation: Blood Rev. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-06 Completed Date: 2007-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708558 Medline TA: Blood Rev Country: Scotland |
Other Details:
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Languages: eng Pagination: 333-42 Citation Subset: IM |
Affiliation:
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H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SBR-2, Tampa, FL 33612, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Survival
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immunology Drug Resistance, Neoplasm* Hematologic Neoplasms / drug therapy*, immunology* Humans Models, Immunological Signal Transduction / immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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