Document Detail

Tumor microenvironment and drug resistance in hematologic malignancies.
MedLine Citation:
PMID:  16920238     Owner:  NLM     Status:  MEDLINE    
Increasing evidence supports the role of the tumor microenvironment in conferring drug resistance as a major cause of relapse and incurability of cancers. The tumor microenvironment consists of normal stromal cells, extracellular matrix, and soluble factors such as cytokines and growth factors. Tumor-tumor cell interaction, tumor-stromal cell interaction, as well as tumor-ECM interaction, all contribute to direct cell contact mediated drug resistance. In addition, soluble factors produced in the tumor microenvironment provide further signals for tumor cell growth and survival. Environment mediated-drug resistance (EM-DR) could be considered as the totality of cell adhesion mediated drug resistance (CAM-DR) and soluble factor mediated drug resistance (SM-DR) produced by the tumor-host interaction. This review focuses on the EM-DR model system and signaling pathways involved in cell survival of hematological malignancies.
Zhi-Wei Li; William S Dalton
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-08-22
Journal Detail:
Title:  Blood reviews     Volume:  20     ISSN:  0268-960X     ISO Abbreviation:  Blood Rev.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  333-42     Citation Subset:  IM    
H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SBR-2, Tampa, FL 33612, United States.
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MeSH Terms
Cell Survival / immunology
Drug Resistance, Neoplasm*
Hematologic Neoplasms / drug therapy*,  immunology*
Models, Immunological
Signal Transduction / immunology

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