Document Detail


Tumor marker production in human bronchial carcinoma xenografts.
MedLine Citation:
PMID:  6291006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 37 human bronchial carcinomas (15 small cell, 10 squamous, six large cell and six adenocarcinomas) have been successfully heterotransplanted into immune-suppressed mice. Monolayer tissue cultures have been established from 23 of the xenograft lines. After contact with tumour cells, supernatant culture medium was analysed by radioimmunoassay for adrenocorticotrophin (ACTH), calcitonin, human chorionic gonadotropin beta subunit (beta HCG) and carcinoembryonic antigen (CEA). Calcitonin production was associated with three (13%) xenograft lines (two small cell, one adenocarcinoma). beta HCG was found in three (13%) lines (one small cell, two large cell anaplastic). CEA was produced in 13 (56.5%) lines (seven small cell, two squamous, one large cell, three adenocarcinomas). ACTH was present in 18 (78.2%) lines (11 small cell, two squamous, two large cell, three adenocarcinomas), but evidence indicates that this hormone is not in all cases produced and secreted by the tumour.
Authors:
A J Shorthouse; S M Carter; M L Ellison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  3     ISSN:  0167-1618     ISO Abbreviation:  Oncodev. Biol. Med.     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8100446     Medline TA:  Oncodev Biol Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / physiopathology
Animals
Carcinoma / physiopathology
Carcinoma, Bronchogenic / physiopathology*
Carcinoma, Small Cell / physiopathology
Carcinoma, Squamous Cell / physiopathology
Cells, Cultured
Cytarabine / pharmacology
Humans
Immunosuppression
Lung Neoplasms / physiopathology*
Mice
Neoplasm Transplantation
Thymectomy
Transplantation, Heterologous
Whole-Body Irradiation
Chemical
Reg. No./Substance:
147-94-4/Cytarabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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