Document Detail


Tumor localization using radiolabeled monoclonal antibodies. An overview.
MedLine Citation:
PMID:  3909809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This essay presents an overview of tumor localization using radiolabeled monoclonal antibodies. In particular the contribution of three major factors--the antibodies, imaging techniques, and various properties of the tumor--are all considered. Despite the fact that monoclonal antibodies are not truly tumor-specific, the evidence suggests that specific tumor localization is possible. In addition, tumor detection may be improved by the use of antibody fragments. The use of isotopes other than iodine to label immunoglobulins as well as single photon emission computerized tomography may also improve tumor resolution. Tumor heterogeneity and the presence of circulating tumor antigens may be self-limiting, but each of these problems can be overcome. The accurate detection of lymph node metastases is a subject of current study, but if feasible it may represent the major contribution of this imaging technology to clinical medicine.
Authors:
J R Zalcberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  8     ISSN:  0277-3732     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-24     Completed Date:  1986-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / diagnostic use
Antibody Affinity
Antibody Specificity
Antigen-Antibody Complex
Antigens, Neoplasm / immunology
Carcinoembryonic Antigen / immunology
Cell Line
Colonic Neoplasms / radionuclide imaging
False Positive Reactions
Humans
Immunoglobulin Fragments / diagnostic use
Immunoglobulin G / diagnostic use
Indium / diagnostic use
Iodine Radioisotopes / diagnostic use*
Lymph Nodes / radionuclide imaging
Mice
Mice, Nude
Neoplasms / blood supply,  immunology,  radionuclide imaging*
Radioisotopes / diagnostic use
Subtraction Technique
Technetium / diagnostic use
Tomography, Emission-Computed / instrumentation
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigen-Antibody Complex; 0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Immunoglobulin Fragments; 0/Immunoglobulin G; 0/Iodine Radioisotopes; 0/Radioisotopes; 7440-26-8/Technetium; 7440-74-6/Indium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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