|Tumor localization using radiolabeled monoclonal antibodies. An overview.|
|PMID: 3909809 Owner: NLM Status: MEDLINE|
|This essay presents an overview of tumor localization using radiolabeled monoclonal antibodies. In particular the contribution of three major factors--the antibodies, imaging techniques, and various properties of the tumor--are all considered. Despite the fact that monoclonal antibodies are not truly tumor-specific, the evidence suggests that specific tumor localization is possible. In addition, tumor detection may be improved by the use of antibody fragments. The use of isotopes other than iodine to label immunoglobulins as well as single photon emission computerized tomography may also improve tumor resolution. Tumor heterogeneity and the presence of circulating tumor antigens may be self-limiting, but each of these problems can be overcome. The accurate detection of lymph node metastases is a subject of current study, but if feasible it may represent the major contribution of this imaging technology to clinical medicine.|
|J R Zalcberg|
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|Type: Comparative Study; Journal Article|
|Title: American journal of clinical oncology Volume: 8 ISSN: 0277-3732 ISO Abbreviation: Am. J. Clin. Oncol. Publication Date: 1985 Dec|
|Created Date: 1986-01-24 Completed Date: 1986-01-24 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 8207754 Medline TA: Am J Clin Oncol Country: UNITED STATES|
|Languages: eng Pagination: 481-9 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Antibodies, Monoclonal / diagnostic use
Antigens, Neoplasm / immunology
Carcinoembryonic Antigen / immunology
Colonic Neoplasms / radionuclide imaging
False Positive Reactions
Immunoglobulin Fragments / diagnostic use
Immunoglobulin G / diagnostic use
Indium / diagnostic use
Iodine Radioisotopes / diagnostic use*
Lymph Nodes / radionuclide imaging
Neoplasms / blood supply, immunology, radionuclide imaging*
Radioisotopes / diagnostic use
Technetium / diagnostic use
Tomography, Emission-Computed / instrumentation
|0/Antibodies, Monoclonal; 0/Antigen-Antibody Complex; 0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Immunoglobulin Fragments; 0/Immunoglobulin G; 0/Iodine Radioisotopes; 0/Radioisotopes; 7440-26-8/Technetium; 7440-74-6/Indium|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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