| Tumor length as a prognostic factor in esophageal malignancy: univariate and multivariate survival analyses. | |
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MedLine Citation:
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PMID: 16496364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Gastrointestinal specialists generally feel that long esophageal tumors carry a worse prognosis and are likely to be more advanced than shorter lesions. Our aim was to investigate the relationship between histologically determined tumor length and aspects of tumor pathology and survival for patients with resected esophageal malignancy. METHODS: Three hundred and nine patients who underwent esophageal resection with curative intent in our unit between 1994 and 2003 were retrospectively analyzed. Pathological details such as TNM stage, differentiation, completeness of surgical resection, and overall stage were collected. Survival data were obtained for each patient and univariate and multivariate analyses were performed. Overall survival was used as the primary endpoint. RESULTS: There were 225 adenocarcinomas, 72 squamous cell carcinomas, and 12 other tumor types with a median tumor length of 3.5 cm (range 0.5-14 cm). Tumor length greater than 3.5 cm was associated with increasing T stage (P = 0.0001), N stage (P = 0.032), overall stage (P = 0.003), and involvement of the longitudinal resection margins (P = 0.02). Univariate analysis found tumor length greater than 3.5 cm was associated with worse overall survival compared with shorter tumors (P = 0.0002). Tumor length remained a significant prognostic factor on multivariate analysis (P = 0.04). Other prognostic factors on multivariate analysis were age, tumor differentiation, nodal involvement, and resection margin status. CONCLUSION: Tumor length greater than 3.5 cm (as determined histologically) is associated with worse disease stage and poor overall patient survival. If preoperative endoscopic tumor length bears a similar relationship, this could assist in patient selection for appropriate treatments. |
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Authors:
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Ewen A Griffiths; Zoe Brummell; Ganesh Gorthi; Susan A Pritchard; Ian McL Welch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of surgical oncology Volume: 93 ISSN: 0022-4790 ISO Abbreviation: J Surg Oncol Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-28 Completed Date: 2006-03-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 258-67 Citation Subset: IM |
Copyright Information:
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(c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Department of Gastrointestinal Surgery, South Manchester University Hospitals NHS Trust, Wythenshawe, Manchester, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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mortality*,
pathology,
surgery Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / mortality*, pathology, surgery Endpoint Determination Esophageal Neoplasms / mortality*, pathology*, surgery Esophagectomy* / mortality Female Follow-Up Studies Humans Male Middle Aged Multivariate Analysis Neoplasm Staging Prognosis Proportional Hazards Models Retrospective Studies Survival Analysis |
| Comments/Corrections | |
Comment In:
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J Surg Oncol. 2006 Mar 15;93(4):257
[PMID:
16496363
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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