Document Detail

Tumor growth inhibition and nutritional effect of D-amino acid solution in AH109A hepatoma-bearing rats.
MedLine Citation:
PMID:  9591236     Owner:  NLM     Status:  MEDLINE    
We examined the inhibitional and nutritional effects of total parenteral nutrition (TPN) containing D-amino acids (D-phenylalanine, D-Phe; D-valine, D-Val; D-leucine, D-Leu; D-methionine, D-Met) on tumor growth in AH109A hepatoma-bearing rats. Five experimental groups were examined: a control amino acid solution group (control group), D-Phe group, D-Val group, D-Leu group and D-Met group. The analysis of tumor volume and weight revealed significant tumor growth inhibition in the D-Val group as compared with the control group. In the D-Val group, decreases of DNA and protein contents in the tumor tissues were also observed. The D-Leu and D-Met groups showed a tendency toward tumor growth inhibition. The protein content in the liver tissues of these two groups was significantly higher as compared with the control group. The DNA content in the liver tissue was also significantly higher in the D-Met group. The body weight including the tumor (on the final day of TPN) was significantly lower in the D-Val group as compared with the control group, but there was no significant difference in the groups for body weights not including tumors (carcass body weight). The hematocrit and hemoglobin values, indicators of anemia, were significantly higher in the D-Val group as compared with the control group. From these results, regarding tumor growth inhibition, the D-Val solution had the strongest inhibitory effect with no negative influence on the host, and improvement of nutritional status was also suggested in the rats that received the D-Leu or D-Met solutions.
T Sasamura; A Matsuda; Y Kokuba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  44     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-07-16     Completed Date:  1998-07-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
Infusion Research Department, Hoechst Marion Roussel Ltd., Shiga, Japan.
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MeSH Terms
Amino Acids / administration & dosage*
Body Weight
DNA, Neoplasm / metabolism
Erythrocyte Count
Hemoglobins / metabolism
Liver / metabolism
Liver Neoplasms, Experimental / metabolism,  pathology*
Neoplasm Proteins / metabolism
Nutritional Status*
Organ Size
Parenteral Nutrition, Total*
Reg. No./Substance:
0/Amino Acids; 0/DNA, Neoplasm; 0/Hemoglobins; 0/Neoplasm Proteins; 0/Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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