Document Detail

Tumor front grading in prediction of survival and lymph node metastases in patients with laryngeal carcinoma.
MedLine Citation:
PMID:  17357309     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Despite innumerous both therapeutic and histopathologic studies that have been performed no morphologic markers are currently available in order to predict the outcome in patients with laryngeal cancer. According to the recent reports nowadays tumor front grading (TFG) is one of the most reliable methods of estimation of the progress of the changes in the peripheral part of tumor and it seems to be one of the technics, which is able to assess the dynamics of the tumor growth quite precisely. In this sudy it was presented direct relation between morphological features of tumor front and survival. MATERIAL AND METHODS: The authors have analysed 120 cases of patients who were operated on the laryngeal squamous cell carcinoma in ENT Department Medical University of Lódź between 1995-2000. Features of the morphologic tumor front grading was performed on H&E-stained sections in the peripheral parts of a tumor. Dependence on tumor grade G, tumor size T, lymph node metastases and survival were analysed. RESULTS: Our study showed that feature such as TFG is very useful in prediction of survival in patients with laryngeal squamous cell carcinoma in comparison to the histological differentiation degree. The statistical analysis showed no significant correlation between TFG score and tumor size T, nodal status N and G feature. CONCLUSIONS: The presented study emphasizes that TFG might influence decisions regarding therapeutic management and could eventually lead to more appropriate and individualized therapy. It is necessary to extend the traditional histopathological diagnosis by TFG, which assesses the dynamics of the malignant process and it seems to be a good prognostic method in prediction of survival of patients with squamous cell carcinoma.
K Starska; A Kulig; M Lukomski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in medical sciences     Volume:  51     ISSN:  1896-1126     ISO Abbreviation:  Adv Med Sci     Publication Date:  2006  
Date Detail:
Created Date:  2007-03-15     Completed Date:  2007-07-05     Revised Date:  2008-05-15    
Medline Journal Info:
Nlm Unique ID:  101276222     Medline TA:  Adv Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  200-4     Citation Subset:  IM    
Department of Otorhinolaryngology, Medical University of Lódź ul. Wandurskiego 3A/22, 93-218 Lódź, Poland.
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MeSH Terms
Carcinoma, Squamous Cell / pathology
Disease-Free Survival
Laryngeal Neoplasms / pathology*
Lymph Nodes / pathology*
Lymphatic Metastasis / diagnosis*
Middle Aged
Neoplasm Staging / methods*
Sensitivity and Specificity

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