| Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. | |
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MedLine Citation:
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PMID: 22713869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent advances in the study of tumor-derived microvesicles reveal new insights into the cellular basis of disease progression and the potential to translate this knowledge into innovative approaches for cancer diagnostics and personalized therapy. Tumor-derived microvesicles are heterogeneous membrane-bound sacs that are shed from the surfaces of tumor cells into the extracellular environment. They have been thought to deposit paracrine information and create paths of least resistance, as well as be taken up by cells in the tumor microenvironment to modulate the molecular makeup and behavior of recipient cells. The complexity of their bioactive cargo-which includes proteins, RNA, microRNA, and DNA-suggests multipronged mechanisms by which microvesicles can condition the extracellular milieu to facilitate disease progression. The formation of these shed vesicles likely involves both a redistribution of surface lipids and the vertical trafficking of cargo to sites of microvesicle biogenesis at the cell surface. Current research also suggests that molecular profiling of these structures could unleash their potential as circulating biomarkers as well as platforms for personalized medicine. Thus, new and improved strategies for microvesicle identification, isolation, and capture will have marked implications in point-of-care diagnostics for cancer patients. |
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Authors:
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Crislyn D'Souza-Schorey; James W Clancy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Genes & development Volume: 26 ISSN: 1549-5477 ISO Abbreviation: Genes Dev. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-20 Completed Date: 2012-08-30 Revised Date: 2013-05-17 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: United States |
Other Details:
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Languages: eng Pagination: 1287-99 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA. cdsouzas@nd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell-Derived Microparticles
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metabolism* Extracellular Space / metabolism Humans Individualized Medicine Neoplasms / metabolism*, pathology* Tumor Markers, Biological / metabolism* Tumor Microenvironment* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA115316/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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