| Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography. | |
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MedLine Citation:
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PMID: 22029362 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We present a magnetic resonance (MR)-guided near-infrared dynamic contrast enhanced diffuse optical tomography (DCE-DOT) system for characterization of tumors using an optical contrast agent (ICG) and a MR contrast agent [Gd-diethylenetriaminepentaacetic acid (DTPA)] in a rat model. Both ICG and Gd-DTPA are injected and monitored simultaneously using a combined MRI-DOT system, resulting in accurate co-registration between two imaging modalities. Fisher rats bearing R3230 breast tumor are imaged using this hybrid system. For the first time, enhancement kinetics of the exogenous contrast ICG is recovered from the DCE-DOT data using MR anatomical a priori information. As tumors grow, they undergo necrosis and the tissue transforms from viable to necrotic. The results show that the physiological changes between viable and necrotic tissue can be differentiated more accurately based on the ICG enhancement kinetics when MR anatomical information is utilized. |
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Authors:
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Yuting Lin; Dave Thayer; Orhan Nalcioglu; Gultekin Gulsen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical optics Volume: 16 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 106015 Citation Subset: IM |
Affiliation:
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University of California, Irvine, Tu and Yuen Center for Functional Onco-Imaging, Irvine, California 92697University of California, Irvine, Department of Radiological Sciences, Irvine, California 92697Pusan National University, Department of Cogno-Mechatronics Engineering, Pusan, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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