Document Detail


Tumor cell-selective antiproliferative effect of the extract from Morinda citrifolia fruits.
MedLine Citation:
PMID:  16619339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The methanol extract from Morinda citrifolia fruits was tested for cytotoxicity activity on the MTT assay. The appearance of cytotoxic changes after exposure to the extract was in a concentration dependent manner. The median lethal concentrations (LC(50)) of the extract in baby hamster kidney (BHK) cells, African green monkey kidney (Vero) cells and human laryngeal carcinoma (Hep2) cells were found to be 2.5, 3 and 5 mg/mL, respectively. A concentration of 0.1 mg/mL of crude extract exhibited cytotoxic activity against breast cancer (MCF7) and neuroblastoma (LAN5) cell lines at 29% and 36%, respectively. The same concentration of extract showed no toxicity to Vero and very little toxicity to BHK (6%) and Hep2 (13%) cells.
Authors:
Teerakul Arpornsuwan; Tadsanee Punjanon
Related Documents :
2347039 - Enhanced retention of cytosine arabinoside and its metabolites and synergistic cytotoxi...
18955299 - Differential growth suppression of human melanoma cells by tea (camellia sinensis) epic...
20816779 - Casearin x exhibits cytotoxic effects in leukemia cells triggered by apoptosis.
20650179 - Heavy metal toxicity following apical and basolateral exposure in the human intestinal ...
3559919 - Bipyridylium herbicide toxicity: effects of paraquat and diquat on isolated rat hepatoc...
16107729 - Cationic sites on granzyme b contribute to cytotoxicity by promoting its uptake into ta...
9634209 - Intracellular ph and chemoresponse to nh4+ in paramecium.
3955419 - Selective modifications of cellular proteins in intratumoral subpopulations of human co...
21955999 - Cytotoxicity of human recombinant arginase i (co)-peg5000 in the presence of supplement...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  20     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-24     Completed Date:  2006-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-7     Citation Subset:  IM    
Affiliation:
Faculty of Allied Health Science, Thammasat University, Pathumthani, Thailand. teerakul@alpha.tu.ac.th
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / analysis*
Cell Line, Tumor
Cell Proliferation / drug effects*
Cercopithecus aethiops
Cricetinae
Drug Screening Assays, Antitumor
Fruit / chemistry*
Humans
Morinda / chemistry*
Plant Extracts / pharmacology*
Vero Cells
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A natural sweetener, Momordica grosvenori, attenuates the imbalance of cellular immune functions in ...
Next Document:  The pharmacological effects of Salvia species on the central nervous system.