Document Detail

Tumor cell-selective antiproliferative effect of the extract from Morinda citrifolia fruits.
MedLine Citation:
PMID:  16619339     Owner:  NLM     Status:  MEDLINE    
The methanol extract from Morinda citrifolia fruits was tested for cytotoxicity activity on the MTT assay. The appearance of cytotoxic changes after exposure to the extract was in a concentration dependent manner. The median lethal concentrations (LC(50)) of the extract in baby hamster kidney (BHK) cells, African green monkey kidney (Vero) cells and human laryngeal carcinoma (Hep2) cells were found to be 2.5, 3 and 5 mg/mL, respectively. A concentration of 0.1 mg/mL of crude extract exhibited cytotoxic activity against breast cancer (MCF7) and neuroblastoma (LAN5) cell lines at 29% and 36%, respectively. The same concentration of extract showed no toxicity to Vero and very little toxicity to BHK (6%) and Hep2 (13%) cells.
Teerakul Arpornsuwan; Tadsanee Punjanon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  20     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-24     Completed Date:  2006-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-7     Citation Subset:  IM    
Faculty of Allied Health Science, Thammasat University, Pathumthani, Thailand.
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MeSH Terms
Antineoplastic Agents, Phytogenic / analysis*
Cell Line, Tumor
Cell Proliferation / drug effects*
Cercopithecus aethiops
Drug Screening Assays, Antitumor
Fruit / chemistry*
Morinda / chemistry*
Plant Extracts / pharmacology*
Vero Cells
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts

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