Document Detail


Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase.
MedLine Citation:
PMID:  19995569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telomerase (hTERT) activation in cancer cells is an invariable finding resulting in the maintenance of telomere lengths and enhanced replicative capacity. Therefore a variety of therapeutic approaches are being investigated to target hTERT, such as hTERT-promoter driven expression of apoptosis inducing genes, inhibiting telomeric RNA (hTR), and anti-sense or siRNA mediated gene silencing. Whereas, the conventional oncogenic role of hTERT has been linked to its ability to induce replicative senescence and immortalization, evidence is accumulating to support non-canonical activity of hTERT in cancer cells. To that end, hTERT has been implicated in redox-mediated events and its expression has been shown to impact cellular redox status via the recruitment of the mitochondria, a critical intracellular source of reactive oxygen species (ROS). Further evidence in support of the role of mitochondria in hTERT biology comes from findings demonstrating localization of hTERT to the mitochondria, and the ability of hTERT inhibitors to induce mitochondrial-dependent apoptosis in target cells. Here we review the emerging evidence to support the involvement of the mitochondria and intracellular ROS as critical mediators of the non-canonical functions/activity of hTERT with potential implications for its therapeutic targeting in cancer cells.
Authors:
Inthrani Raja Indran; Manoor Prakash Hande; Shazib Pervaiz
Related Documents :
12081329 - Tuning up or down the uv-induced apoptosis in chinese hamster ovary cells with cell cyc...
21186369 - Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions o...
18241249 - Tumour growth inhibition by an imidazoquinoline is associated with c-myc down-regulatio...
21317379 - Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: eff...
21181559 - Normoxically overexpressed hypoxia inducible factor 1-alpha is involved in arsenic trio...
21512579 - Targeted liposomal drug delivery to monocytes and macrophages.
25275009 - Activation of mitochondrial protease oma1 by bax and bak promotes cytochrome c release ...
8921439 - Induction of fas-dependent apoptosis in synovial infiltrating cells in rheumatoid arthr...
17922949 - Altered signalling and gene expression associated with the immune system and the inflam...
Publication Detail:
Type:  Journal Article; Review     Date:  2009-12-06
Journal Detail:
Title:  Molecular aspects of medicine     Volume:  31     ISSN:  1872-9452     ISO Abbreviation:  Mol. Aspects Med.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603128     Medline TA:  Mol Aspects Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  21-8     Citation Subset:  IM    
Copyright Information:
2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Homeostasis
Humans
Mitochondria / enzymology*,  metabolism
Neoplasms / enzymology*,  metabolism,  pathology
Oxidation-Reduction
Reactive Oxygen Species / metabolism
Telomerase / metabolism*
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of a positive allosteric modulator of mGluR(5) ADX47273 on conditioned avoidance response an...
Next Document:  Mitochondria as targets in angiogenesis inhibition.