Document Detail


Tumor cell formation by normal somatic cells fusing and cancer prevention prospects.
MedLine Citation:
PMID:  16181744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malignant transformation might be ascribed to one of the rather widespread processes taking place in the organism daily and being genetically inherited in a normal somatic cell. In order that normal cells are transformed into malignant ones, they should undergo the following two stages: (1) initiation - the precancerous cell (first-stage synkarion) formation, and (2) promotion - the true tumor cell (second-stage synkaryon) formation. For promoting the tumor process, i.e. transformation into a true tumor synkaryon, first - stage synkaryon (precancerous cell) should go through the next stage/stages of development at the molecular and subcellular level. In a tumor synkaryon, in particular in its plasma membrane, most probably the antigenic mosaics of normal precursor cells is inherited and, therefore, such cells "escape" the effect of the immune forces of the body. In other words, antigenic determinants existing on the surface of normal initial (parent) precursor cells condition inaction of the so-called immune surveillance. The cancer prevention concept implies synchronous conversion of a tumor cell into the stage of nonviable polykaryocytes. In addition, for preventing this fatal disease the inhibition of the process of approaching and further adhesion of normal somatic cells would suffice. The expected outcome would be the creation in the body of the conditions when somatic cells are incapable of close contacts with each other (not injurious for organism). This will completely exclude the fusion of cells and then nuclei and reduce thus to a minimum the possibility of cancer cell development.
Authors:
G K Gogichadze; E V Misabishvili; T G Gogichadze
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Publication Detail:
Type:  Journal Article     Date:  2005-09-21
Journal Detail:
Title:  Medical hypotheses     Volume:  66     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2006  
Date Detail:
Created Date:  2005-11-08     Completed Date:  2006-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Affiliation:
Georgian State Medical Academy, 29.1 Chavchavadze Avenue, Tbilisi 0179, Georgia, USA. gogi_gogichadze@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Cell Fusion*
Cell Transformation, Neoplastic / pathology*
Humans
Models, Biological*
Neoplasms / physiopathology*,  prevention & control*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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