| Tumor-Released Survivin Induces a Type-2 T Cell Response and Decreases Cytotoxic T Cell Function, in Vitro. | |
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MedLine Citation:
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PMID: 22322461 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Clinical studies of T cell profiles from cancer patients have shown a skewing toward a type-2 T cell response with decreased cytotoxic T cell function. However, the primary cause of this shift remains unknown. Here we show that tumor-released Survivin, an inhibitor of apoptosis (IAP) protein and tumor-specific antigen, is taken up by T cells and alters their response. The addition of Survivin to T cell cultures resulted in decreased T cell proliferation and reduced cytotoxic CD8(+) T cell function. Additionally, type 1 cell numbers and IFN-γ and IL-2 production were significantly reduced, while IL-4 release and type 2 T cell numbers increased. In contrast, the function and numbers of Th17 and T regulatory cells were not affected. These studies show that tumor-released Survivin modulates T cells resulting in a phenotype similar to that observed in cancer patients with a polarity shift from a type 1 to a type 2 response. |
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Authors:
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Jessica M S Jutzy; Salma Khan; Malyn May Asuncion-Valenzuela; Terry-Ann M Milford; Kimberly J Payne; Nathan R Wall |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-10 |
Journal Detail:
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Title: Cancer microenvironment : official journal of the International Cancer Microenvironment Society Volume: - ISSN: 1875-2284 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101322634 Medline TA: Cancer Microenviron Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center for Health Disparities & Molecular Medicine, Department of Basic Sciences, Loma Linda University, 11085 Campus Street, Mortensen Hall Room 162, Loma Linda, CA, 92350, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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