| Tumor Necrosis Factor-alpha- and interleukin-1-induced cellular responses: coupling proteomic and genomic information. | |
| | |
MedLine Citation:
|
PMID: 17503796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pro-inflammatory cytokines, Tumor Necrosis Factor-alpha (TNFalpha) and Interleukin-1 (IL-1) mediate the innate immune response. Dysregulation of the innate immune response contributes to the pathogenesis of cancer, arthritis, and congestive heart failure. TNFalpha- and IL-1-induced changes in gene expression are mediated by similar transcription factors; however, TNFalpha and IL-1 receptor knock-out mice differ in their sensitivities to a known initiator (lipopolysaccharide, LPS) of the innate immune response. The contrasting responses to LPS indicate that TNFalpha and IL-1 regulate different processes. A large-scale proteomic analysis of TNFalpha- and IL-1-induced responses was undertaken to identify processes uniquely regulated by TNFalpha and IL-1. When combined with genomic studies, our results indicate that TNFalpha, but not IL-1, mediates cell cycle arrest. |
| | |
Authors:
|
Lee W Ott; Katheryn A Resing; Alecia W Sizemore; Joshua W Heyen; Ross R Cocklin; Nathan M Pedrick; H Cary Woods; Jake Y Chen; Mark G Goebl; Frank A Witzmann; Maureen A Harrington |
Related Documents
:
|
20582456 - The role of the inflammasome in nonmyeloid cells. 8144966 - Co-ligation of cd31 and fc gamma rii induces cytokine production in human monocytes. 7843796 - Heterogeneity of kupffer cells and splenic, alveolar, and peritoneal macrophages for th... 12519386 - Butyrate modulates intestinal epithelial cell-mediated neutrophil migration. 1983966 - Fc-receptor-mediated phagocytosis: abnormalities associated with diabetes mellitus. 23559276 - Kinetics of apoptosis and expression of apoptosis-related proteins in rat ca3 hippocamp... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-05-16 |
Journal Detail:
|
Title: Journal of proteome research Volume: 6 ISSN: 1535-3893 ISO Abbreviation: J. Proteome Res. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-06-01 Completed Date: 2007-07-18 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: United States |
Other Details:
|
Languages: eng Pagination: 2176-85 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, MS 4053, Indianapolis, Indiana 46202, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Cycle
/
drug effects Cell Line Cell Membrane Permeability / drug effects Cytoplasm / drug effects, genetics, metabolism Genomics* Humans Hypoxia-Inducible Factor 1, alpha Subunit / genetics, metabolism Interleukin-1 / pharmacology* Mitochondrial Membranes / drug effects Proteins / analysis, genetics Proteomics* RNA, Messenger / analysis Transcription, Genetic / drug effects Tumor Necrosis Factor-alpha / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
R21 AA015698-01/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Interleukin-1; 0/Proteins; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced a1 fragmentation for dimethylated proteins and its applications for N-terminal identificati...
Next Document: Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of t...