| Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression Correlates to Temporomandibular Joint Disk Degeneration. | |
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MedLine Citation:
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PMID: 21403533 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study investigated if tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) immunohistochemical expression in human temporomandibular joint (TMJ)-degenerated disks correlates to the degree of tissue damage to elucidate the possible involvement of this apoptotic pathway in TMJ disk degeneration. Twenty-one TMJ displaced disk from 12 patients were affected by anterior disk displacement with reduction and 9 by anterior disk displacement without reduction processed immunohistochemically with TRAIL antibody. Histopathologic grading of the disk degeneration was carried out in each specimen. The mean histopathologic score of the TMJ degenerated disks was 4.77 ± 1.26 (minimum, 2; maximum, 7). Immunolabeling for TRAIL was detected in the cytoplasm of the TMJ disk cells in every sample, although with different patterns of reactivity. The degree of TRAIL immunostaining was correlated to the histopathologic degeneration score obtained from the sample (Spearman ρ = 0.617). Therefore, cell loss due to the involvement of TRAIL apoptotic pathway seems, in part, responsible for TMJ disk degeneration. |
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Authors:
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Rosalia Leonardi; Luis Eduardo Almeida; Mugurel Rusu; Edoardo Sicurezza; Giuseppe Palazzo; Carla Loreto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-9 |
Journal Detail:
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Title: The Journal of craniofacial surgery Volume: - ISSN: 1536-3732 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010410 Medline TA: J Craniofac Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Dentistry, Faculty of Dentistry, University of Catania, Policlinico Universitario, Italy; †Department of Anatomy, Diagnostic Pathology, Forensic Medicine, Hygiene and Public Health, University of Catania, Italy; ‡Center for Health and Biological Sciences, Pontifical Catholic University of Paraná, Curitiba, Brazil; and §Department of Anatomy and Embryology, Faculty of Dental Medicine, University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania. |
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