Document Detail


Tumor Immunomodulation: Mucins in resistance to initiation and maturation of immune response against tumors.
MedLine Citation:
PMID:  23298229     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mucins are high molecular weight glycoproteins designed for cellular protection and sensing the external environment. Aberrant glycosylation and altered mucin expression seen in cancers are implicated in mucin dependent refraction to immunosurveilance and immunosuppressive induction around the tumor. Though mucins provide molecular targets for immune system's tumor recognition, their characteristics dictate that the nature of immune response required for recognition and lyses of mucin expressing tumors need to follow predominantly a MHC - unrestricted, αβ TCR mediated effector cell response. Frequent loss of DC maturation and elimination of reactive lymphocytes, altered adhesive and anti-adhesive properties of the mucins promote tumor survival and escape from the immune response.
Authors:
Arachimani Anandkumar; Halagowder Devaraj
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  -     ISSN:  1365-3083     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Scandinavian Journal of Immunology © 2013 Blackwell Publishing Ltd.
Affiliation:
University of Madras.
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