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Tubulointerstitial nephritis with uveitis (TINU) syndrome : A relatively rare rheumatological differential diagnosis with unexplained uveitis.
MedLine Citation:
PMID:  23340909     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The tubulo-interstitial nephritis and uveitis (TINU) syndrome, first described in 1975, is a rare disease most probably of autoimmune origin that is characterized by unilateral or bilateral uveitis and tubulointerstitial nephritis. Most patients are adolescents and it is sometimes associated with other autoimmune diseases, such as spondyloarthritis, rheumatoid arthritis and hyperthyroidosis. This article reports the case of a 43-year-old female patient who presented with refractory recurrent bilateral uveitis despite therapy with high doses of corticosteroids in combination with cyclosporin. When the patient was referred to this hospital for rheumatological examination after almost 1 year of therapy, mild renal insufficiency and proteinuria were found. The kidney biopsy revealed interstitial nephritis, partly crescent-shaped and partly chronic. A diagnosis of TINU syndrome was made and treatment with adalimumab in combination with methotrexate was started. The favorable clinical outcome indicated that tumor necrosis factor (TNF) alpha may play an important role in the pathogenesis of TINU syndrome.
Authors:
U Häusler; B Guminski; U Helmchen; K Kisters; C Heinz; J Braun
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Zeitschrift fur Rheumatologie     Volume:  -     ISSN:  1435-1250     ISO Abbreviation:  Z Rheumatol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0414162     Medline TA:  Z Rheumatol     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Rheumazentrum Ruhrgebiet, Landgrafenstr. 15, 44652, Herne, Deutschland, U.Haeusler@rheumazentrum-ruhrgebiet.de.
Vernacular Title:
Tubulointerstitielle-Nephritis-mit-Uveitis (TINU)-Syndrom : Eine eher seltene rheumatologische Differenzialdiagnose bei unklarer Uveitis.
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