Document Detail

Tubulointerstitial inflammation, cast formation, and renal parenchymal damage in experimental pyelonephritis.
MedLine Citation:
PMID:  6650659     Owner:  NLM     Status:  MEDLINE    
Some basic changes in experimental pyelonephritis were studied by transmission and scanning electron microscope. Initially, bacteria settled and multiplied in capillaries and venules. Leukocytes first marginated and then escaped from the capillaries, particularly to the wide peritubular interstitium. After opening the tubular basement membrane, the infiltrating leukocytes were immediately localized in the tubular wall between epithelial cells but were never seen between the epithelial cells and the underlying basement membrane. The inflammatory cells seemed not to be able to pass through the tight junctions of the nonnecrotic tubular epithelium. As a consequence of severe inflammatory injury, the tight junctions exhibited alterations of intermediate junction type. Where circumscribed necrosis of the tubular walls occurred, leukocytes appeared in the lumen. Thus, pus casts originated from these sites, apparently as drainage of interstitial abscesses. The secondary/regressive and regenerative/tubular changes were similar to those occurring after various tubular lesions.
B Iványi; J Ormos; J Lantos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  113     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2013-06-12    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-8     Citation Subset:  AIM; IM    
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MeSH Terms
Abscess / pathology
Bacterial Infections / pathology*
Basement Membrane / ultrastructure
Kidney Cortex / ultrastructure
Kidney Tubules / ultrastructure*
Leukocytes / pathology
Microscopy, Electron, Scanning
Nephritis, Interstitial / pathology*
Pyelonephritis / pathology*
Rats, Inbred Strains

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