| Tubuloglomerular feedback activity after glomerular immune injury. | |
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MedLine Citation:
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PMID: 2750925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tubuloglomerular feedback responses were examined in control euvolemic and glomerulonephritic rats 4 wk after administration of antiglomerular basement membrane antibody (AGBM). Single-nephron glomerular filtration rate (SNGFR) was reduced approximately 30% in AGBM rats. Tubuloglomerular feedback responses were also tested with both artificial and native tubular fluid. SNGFR was evaluated at 0, 10, 20, 30, and 40 nl/min. Tubuloglomerular feedback response was present in both control and AGBM rats, although there was a shift in turning point or perfusion rate down and leftward at which SNGFR decreased in the AGBM rats. No difference in tubuloglomerular feedback responses was observed between artificial and native tubular fluids. In this model of moderate glomerulonephritis, tubuloglomerular feedback activity appears to be appropriate and intact, and the composition of the fluid entering the loop of Henle does not appear to determine or to be a condition for the presence or absence of tubuloglomerular feedback activity. |
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Authors:
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O W Peterson; L C Gushwa; C B Wilson; R C Blantz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 257 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-08-16 Completed Date: 1989-08-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: F67-71 Citation Subset: IM |
Affiliation:
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Department of Medicine, Veterans Administration Medical Center, San Diego, California 92161. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basement Membrane / immunology Feedback Glomerular Filtration Rate Glomerulonephritis / physiopathology Homeostasis Kidney Glomerulus / immunology*, physiology Kidney Tubules / physiology* Male Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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DK-20043/DK/NIDDK NIH HHS; DK-28602/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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