Document Detail


Tubulin and actin interplay at the T cell and antigen-presenting cell interface.
MedLine Citation:
PMID:  22566814     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
T cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However, growing evidence shows that their roles on T cell activation are more dynamic than merely serving as tracks or scaffold for different molecules. The crosstalk between both skeletons may be important for the formation and movement of the lamella at the immunological synapse by increasing the adhesion of the T cell to the antigen-presenting cells (APC), thus favoring the transport of components toward the plasma membrane and in turn regulating the T-APC intercellular communication. Microtubules and F-actin appear to be essential for the transport of the different signaling microclusters along the membrane, therefore facilitating the propagation of the signal. Finally, they can also be important for regulating the endocytosis, recycling, and degradation of the T cell receptor signaling machinery, thus helping both to sustain the activated state and to switch it off.
Authors:
Noa Beatriz Martín-Cófreces; Balbino Alarcón; Francisco Sánchez-Madrid
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Publication Detail:
Type:  Journal Article     Date:  2011-07-04
Journal Detail:
Title:  Frontiers in immunology     Volume:  2     ISSN:  1664-3224     ISO Abbreviation:  Front Immunol     Publication Date:  2011  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101560960     Medline TA:  Front Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  24     Citation Subset:  -    
Affiliation:
Departamento de Biología Vascular e Inflamación, Centro Nacional de Investigaciones Cardiovasculares Madrid, Spain.
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