| Tubular reabsorption rates for myoglobin in the isolated perfused rat kidney. | |
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MedLine Citation:
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PMID: 3709065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renal handling of myoglobin has been studied in the isolated perfused rat kidney. Myoglobin was freely filtered. Reabsorption by the renal tubules showed saturation kinetics with a relatively low maximum rate of reabsorption (Tmax) of 27-30 micrograms min-1 g-1 wet wt. at a perfusate concentration of 70-80 micrograms/ml. Myoglobin reabsorption is therefore much less than that reported for immunoglobulin light chain or lysozyme in this model. Large increases in sodium and water excretion produced by omission of oncotic agent from the perfusate did not alter the kinetics of myoglobin reabsorption. The use of bovine serum albumin as oncotic agent in the perfusate prevented the tubular reabsorption of myoglobin. Small amounts of albumin are filtered by the isolated perfused kidney and it is postulated that this albumin interferes with tubular reabsorption of myoglobin. |
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Authors:
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P J Ratcliffe; M P Esnouf; J G Ledingham |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 70 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-06-27 Completed Date: 1986-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 595-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Ficoll / metabolism Glomerular Filtration Rate Kidney Tubules / metabolism* Male Myoglobin / metabolism* Perfusion Rats Rats, Inbred Strains Serum Albumin, Bovine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Myoglobin; 0/Serum Albumin, Bovine; 25702-74-3/Ficoll |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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