Document Detail

Tubular proteinuria in pre-term and full-term infants.
MedLine Citation:
PMID:  16550364     Owner:  NLM     Status:  MEDLINE    
Predictors of tubular proteinuria (alpha 1-M/crea ratio >10 mg/mmol) were sought in 100 infants of 24-32 weeks' (group 1) and 69 of 34-42 weeks' gestation (group 2). Random spot urine samples were obtained in the former group at the ages of 0-3 days, at 1-2 weeks and thereafter at 2-week intervals until the disappearance of tubular proteinuria, and in the latter one sample at a mean (SD) of 3.0 days' (1.3) age. In group 1, gestational age correlated negatively with the first urinary alpha 1-M/crea ratio. The highest urinary alpha 1-M/crea ratios [median (range) 39.1 mg/mmol (9.5-268.9)] occurred at a median (range) of 5 days' (1-42) age. Low gestational age and the need for inotropes predicted tubular proteinuria early after birth, whereas low gestation and long duration of ventilator treatment predicted the highest alpha 1-M/crea ratios. Prolonged vancomycin treatment and low gestational age were associated with delayed normalization of tubular proteinuria. In group 2 no significant risk factors for tubular proteinuria were found. The urinary alpha 1-M/crea ratio seems to be a sensitive indicator of renal tubular function in neonates, with low gestational age, the need for inotropes and prolonged assisted ventilation being predictors of increased tubular proteinuria. Long vancomycin courses should be avoided in pre-term infants in view of the prolonged adverse renal effects.
Riitta Ojala; Marja Ala-Houhala; Aimo P T Harmoinen; Tiina Luukkaala; Jukka Uotila; Outi Tammela
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Publication Detail:
Type:  Journal Article     Date:  2005-11-17
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  21     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2006-09-29     Revised Date:  2006-10-02    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Department of Pediatrics, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland.
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MeSH Terms
Alpha-Globulins / urine*
Anti-Bacterial Agents / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Infant, Newborn
Infant, Premature, Diseases / urine*
Kidney Tubules / drug effects,  metabolism,  physiology*
Proteinuria / urine*
Reg. No./Substance:
0/Alpha-Globulins; 0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/alpha-1-microglobulin
Erratum In:
Pediatr Nephrol. 2006 Sep;21(9):1333

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