| Tubular proteinuria and glomerular filtration 6 years after puumala hantavirus-induced acute interstitial nephritis. | |
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MedLine Citation:
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PMID: 19390211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: We previously found increased urinary protein excretion, glomerular filtration rate (GFR) and blood pressure in a retrospective analysis of patients with previous nephropathia epidemica (NE). Here, we evaluated the long-term outcome after NE in a prospectively recruited patient group. METHODS: Proteinuria, GFR and ambulatory 24-hour blood pressure were assessed 4-7 years (mean 6) after acute NE in 37 patients, and these values were compared to those from 38 seronegative controls. RESULTS: Six years after NE, the prevalence of elevated urinary alpha(1)-microglobulin excretion was higher in the patients than controls (9/35 vs. 1/38; p = 0.005). The patients also had higher urinary protein excretion (0.17 +/- 0.05 vs. 0.14 +/- 0.04 g/day; p = 0.006), GFR (119 +/- 19 vs. 109 +/- 14 ml/min/1.73 m(2); p = 0.016) and mean systolic (123 +/- 11 vs. 117 +/- 9 mm Hg; p = 0.012), nighttime systolic (109 +/- 11 vs. 100 +/- 9 mm Hg; p = 0.001) and nighttime diastolic blood pressure (70 +/- 7 vs. 66 +/- 7 mm Hg; p = 0.035) than the controls. CONCLUSIONS: These results confirm our previous findings of a higher prevalence of tubular proteinuria and increased urinary protein excretion, GFR and systolic blood pressure 6 years after acute NE. |
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Authors:
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Marja H Miettinen; Satu M Makela; Ilpo O Ala-Houhala; Heini S Huhtala; Tiit Koobi; Antti I Vaheri; Amos I Pasternack; Ilkka H Porsti; Jukka T Mustonen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-23 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 112 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-29 Completed Date: 2009-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c115-20 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine, Central Hospital of Jyvaskyla, Jyvaskyla, Finland. marja.miettinen@ksshp.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Glomerular Filtration Rate* Hemorrhagic Fever with Renal Syndrome / complications*, diagnosis* Humans Kidney Tubules, Proximal / pathology Longitudinal Studies Male Middle Aged Nephritis, Interstitial / diagnosis*, etiology* Proteinuria / diagnosis*, etiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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