Document Detail

Tubular handling of sodium following immersion to the neck and salt-induced volume expansion.
MedLine Citation:
PMID:  7107203     Owner:  NLM     Status:  MEDLINE    
We wished to compare the natriuretic and diuretic effect of extracellular volume expansion (ECVE) with 0.9% NaCl to that obtained with up-to-the-neck immersion (NI) in healthy volunteers. Clearance techniques during maximal antidiuretic hormone suppression were utilized to pinpoint the sites of tubular NaCl reabsorption. Mean glomerular filtration rate (GFR) did not differ significantly between ECVE and NI; mean rate of sodium excretion during ECVE was significantly greater than during NI, whereas mean water clearance for a given rate of distal delivery was higher with NI than with ECVE. Our findings suggest that ECVE is associated with greater natriuresis than NI, despite the equality of filtered sodium loads and of distal deliveries under both these procedures.
J Rapoport; C Chaimovitz; A Lisac; O S Better
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  18     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  675-8     Citation Subset:  IM    
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MeSH Terms
Extracellular Space / physiology
Kidney Tubules / physiology*
Sodium Chloride / pharmacology
Reg. No./Substance:
7647-14-5/Sodium Chloride

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