Document Detail

'Tubular' epithelioid cell nevus: a new variant of Spitz's nevus.
MedLine Citation:
PMID:  9821077     Owner:  NLM     Status:  MEDLINE    
The term Spitz's nevus refers to a large spectrum of nevi composed of spindle and/or epithelioid cells. We report on a hitherto undescribed tubular variant of a dermal epithelioid nevus, characterized by aggregates composed exclusively of cuboidal cells with the prominent feature of tubular or microcystic structures. Immunohistochemically, the epithelioid cells expressed melanocytic markers (S-100, NKI/C3) lacking markers for cytokeratin or carcinoembryonic antigen. The three-dimensional analysis of the lesions by confocal laser scanning microscopy revealed the structural configuration of tubular or microcystic empty spaces bordered by cuboidal nevus cells. This rare variant of epithelioid nevus is another example for the remarkable diversity of Spitz's nevi.
G Burg; W Kempf; M Höchli; T Huwyler; R G Panizzon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  25     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-19     Completed Date:  1999-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  475-8     Citation Subset:  IM    
Department of Dermatology, University Hospital Zurich, Switzerland.
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MeSH Terms
Image Processing, Computer-Assisted
Microscopy, Confocal
Nevus, Epithelioid and Spindle Cell / chemistry,  pathology*
S100 Proteins / analysis
Skin Neoplasms / chemistry,  pathology*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/S100 Proteins; 0/Tumor Markers, Biological
Comment In:
J Cutan Pathol. 1999 Jul;26(6):315-7   [PMID:  10472762 ]

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