| Tubular (acinar) transformation of the choroid plexus epithelium. | |
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MedLine Citation:
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PMID: 12455886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The choroid plexus in the normal state shows a beautiful papillary (or villous) architecture supported by the intricately ramifying, thin fibrovascular stroma. This configuration is retained in benign and malignant neoplasms derived therefrom. The choroid plexus was involved in the pathological process of leukemic cell infiltration in one case reported here and in chronic cryptococcal leptomeningitis in the other case. The epithelial cells of the choroid plexus of the lateral ventricle were arranged extensively in a tubular (acinar) configuration, in association with remarkable stromal fibrosis caused by an infiltration of leukemic or inflammatory cells. In addition, choroid plexus epithelial cells in the first case contained a moderate amount of intracytoplasmic glycogen. These two cases indicate that the non-neoplastic choroid plexus epithelium can undergo transformation into a tubular (acinar) structure as a response or adaptation to the fibrotic processes of the stroma. This finding should be differentiated from metastatic adenocarcinoma. This finding also provides some suggestions as to the pathogenesis of "tubular (acinar) adenoma," a rare variant of benign choroid plexus neoplasm. |
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Authors:
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Masayuki Shintaku |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain tumor pathology Volume: 19 ISSN: 1433-7398 ISO Abbreviation: Brain Tumor Pathol Publication Date: 2002 |
Date Detail:
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Created Date: 2002-11-28 Completed Date: 2002-12-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9716507 Medline TA: Brain Tumor Pathol Country: Japan |
Other Details:
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Languages: eng Pagination: 31-4 Citation Subset: IM |
Affiliation:
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Department of Pathology, Osaka Red Cross Hospital, Tennoji, Osaka 543-8555, Japan. shintaku@orion.ocn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arachnoid
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pathology Choroid Plexus / pathology* Cryptococcosis / complications, pathology Diagnosis, Differential Epithelium / pathology* Female Fibrosis / complications Humans Leukemia, T-Cell / complications, pathology Male Meningitis, Cryptococcal / complications, pathology Middle Aged |
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