| Tubocurarine and pancuronium: a pharmacokinetic view. | |
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MedLine Citation:
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PMID: 7386849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review is an attempt to bring together the pharmacokinetic data on d-tubocurarine and pancuronium with clinical observations on relaxant dosage and effect. The modelling techniques used here represent an oversimplification of the relationships between relaxant plasma concentration and response as they do not predict either the time of onset of paralysis or its peak intensity. However, they do enable calculation of a bolus dose of relaxant required to achieve a particular intensity of paralysis for the average patient once pseudo-distribution equilibrium has been achieved. This has been further extended to predict the cumulation of the relaxants with subsequent dosage in average patients. Suggested regimens incorporating bolus and infusion doses of the relaxants to achieve continuous neuromuscular blockade have been calculated also. Averaged pharmacokinetic parameters derived from patients with renal or hepatic dysfunction have been used to predict the likely duration and intensities of paralysis for the relaxants. |
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Authors:
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C A Shanks; A A Somogyi; M I Ramzan; E J Triggs |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 8 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-08-15 Completed Date: 1980-08-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 4-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dose-Response Relationship, Drug Humans Kinetics Pancuronium / metabolism* Tubocurarine / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Pancuronium; 57-95-4/Tubocurarine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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