Document Detail


Tuberous sclerosis complex with oral manifestations: A case report and literature review.
MedLine Citation:
PMID:  20711158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction: Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and enamel hypoplasia. Clinical Case: A 35-year-old woman diagnosed with TSC presented with a reactive fibroma of considerable size and rapid growth in the region of the right lower third molar. Discussion: In the present case the association of TSC with dental malpositioning gave rise to a rapidly evolving reactive fibroma of considerable diameter. Few similar cases can be found in the literature. Patients with TSC present mutations of the TSC1 and TSC2 genes, which intervene in cell cycle regulation and are important for avoiding neoplastic processes. No studies have been found associating TSC with an increased risk of oral cancer, though it has been shown that the over-expression of TSC2 could exert an antitumor effect. Careful oral and dental hygiene, together with regular visits to the dentist, are needed for the prevention and early detection of any type of oral lesion. The renal, pulmonary and cardiac alterations often seen in TSC must be taken into account for the correct management of these patients.
Authors:
K Harutunian; R Figueiredo; C Gay-Escoda
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Publication Detail:
Type:  Journal Article     Date:  2011-07-01
Journal Detail:
Title:  Medicina oral, patología oral y cirugía bucal     Volume:  16     ISSN:  1698-6946     ISO Abbreviation:  Med Oral Patol Oral Cir Bucal     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231694     Medline TA:  Med Oral Patol Oral Cir Bucal     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  e478-81     Citation Subset:  D; IM    
Affiliation:
Centro Médico Teknon, Instituto de investigación IDIBELL, C/ Vilana 12, 08022 Barcelona (Spain), cgay@ub.edu.
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