Document Detail

Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum.
MedLine Citation:
PMID:  11995668     Owner:  NLM     Status:  MEDLINE    
Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 microg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5beta-spirostane-1beta,3beta-diol 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranoside.
Sheng-Min Sang; Min-Liang Zou; Xiong-Wen Zhang; Ai-Na Lao; Zhong-Liang Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  4     ISSN:  1028-6020     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-11-12     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai.
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MeSH Terms
Allium / chemistry*
Leukemia, Promyelocytic, Acute / pathology
Molecular Structure
Saponins / chemistry,  isolation & purification*,  pharmacology
Seeds / chemistry
Spectrum Analysis
Toxicity Tests
Tumor Cells, Cultured
Reg. No./Substance:
0/Saponins; 0/tuberoside M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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