| Tuberculum sellae meningioma symptomatic during pregnancy: pathophysiological considerations. | |
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MedLine Citation:
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PMID: 18213441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 31 year old woman in her second pregnancy presented in the 31st (+4) week of gestation with progressive visual impairment of the right eye. Magnetic resonance imaging (MRI) demonstrated a tuberculum sellae meningioma that was displaced upward by a markedly enlarged pituitary gland. Neuro-ophthalmological follow-up examinations showed a progressive decrease of visual acuity and right temporal field loss. Therefore, a caesarean section was performed in the 34th (+8) week. The meningioma was removed three days after childbirth via a right-sided pterional approach. Post-operatively, visual function was completely restored. Immunohistochemical examination showed positive staining for progesterone receptors (PR) in approximately 50% of tumour cells. Enlargement of the pituitary gland during late pregnancy in conjunction with a preexisting tuberculum sellae meningioma is the most likely pathophysiological factor responsible for visual loss. Enlargement of the PR-positive meningioma in the hormonal milieu of pregnancy might have contributed additionally to visual loss. |
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Authors:
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F H Ebner; A Bornemann; H Wilhelm; U Ernemann; J Honegger |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-01-23 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 150 ISSN: 0942-0940 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-07 Completed Date: 2008-03-27 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 189-93; discussion 193 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University Hospital Tuebingen, Tuebingen, Germany. florianebner@virgilio.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Meningeal Neoplasms / pathology*, physiopathology Meningioma / pathology*, physiopathology Pregnancy Pregnancy Complications, Neoplastic / pathology*, physiopathology Sella Turcica Vision Disorders / etiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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