Document Detail

Tuberculum sellae meningioma symptomatic during pregnancy: pathophysiological considerations.
MedLine Citation:
PMID:  18213441     Owner:  NLM     Status:  MEDLINE    
A 31 year old woman in her second pregnancy presented in the 31st (+4) week of gestation with progressive visual impairment of the right eye. Magnetic resonance imaging (MRI) demonstrated a tuberculum sellae meningioma that was displaced upward by a markedly enlarged pituitary gland. Neuro-ophthalmological follow-up examinations showed a progressive decrease of visual acuity and right temporal field loss. Therefore, a caesarean section was performed in the 34th (+8) week. The meningioma was removed three days after childbirth via a right-sided pterional approach. Post-operatively, visual function was completely restored. Immunohistochemical examination showed positive staining for progesterone receptors (PR) in approximately 50% of tumour cells. Enlargement of the pituitary gland during late pregnancy in conjunction with a preexisting tuberculum sellae meningioma is the most likely pathophysiological factor responsible for visual loss. Enlargement of the PR-positive meningioma in the hormonal milieu of pregnancy might have contributed additionally to visual loss.
F H Ebner; A Bornemann; H Wilhelm; U Ernemann; J Honegger
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-01-23
Journal Detail:
Title:  Acta neurochirurgica     Volume:  150     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-07     Completed Date:  2008-03-27     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  189-93; discussion 193     Citation Subset:  IM    
Department of Neurosurgery, University Hospital Tuebingen, Tuebingen, Germany.
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MeSH Terms
Meningeal Neoplasms / pathology*,  physiopathology
Meningioma / pathology*,  physiopathology
Pregnancy Complications, Neoplastic / pathology*,  physiopathology
Sella Turcica
Vision Disorders / etiology*

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