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Tuberculous lymphadenopathy: a multicentre operational study of 6-month thrice weekly directly observed treatment.
MedLine Citation:
PMID:  23317960     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
SETTING: Eight operational locations for the Revised National Tuberculosis Control Programme in six Indian states.
OBJECTIVE: To assess the 6-month efficacy of an intermittent thrice-weekly directly observed treatment (DOT) regimen for tuberculous peripheral adenopathy and the need for prolongation of treatment to 9 months for non-resolution of lymphadenopathy.
DESIGN: Patients aged >5 years with tuberculous lymphadenopathy were included in the study. Patients were evaluated for resolution at repeat visits following treatment. Those with poor resolution at 6 months were randomised to extended treatment up to 9 months or observation without additional treatment.
RESULTS: Resolution of lymphadenopathy was observed at the end of 6 months in 517/551 (93.8%) patients. There was a significant difference in response among patients with and those without the presence of systemic symptoms. There was no association between treatment response and number, size, site, consistency and matting of lymphadenopathy. No differences in response were seen in the remaining 34 patients with or without extended treatment.
CONCLUSION: The operational efficacy of 6-month thrice-weekly DOT for peripheral tubercular lymphadenopathy was satisfactory. There was no evidence of additional benefits of prolonging treatment to 9 months.
Authors:
S K Jindal; A N Aggarwal; D Gupta; Z Ahmed; K B Gupta; A K Janmeja; S Kashyap; M Singh; A Mohan; J Whig
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  17     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  234-9     Citation Subset:  IM    
Affiliation:
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
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