| Tuberculous arthritis--a fourteen-year experience at a tertiary teaching hospital in Taiwan. | |
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MedLine Citation:
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PMID: 18087629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: To characterize the clinical and microbiological features of tuberculous arthritis and to clarify the factors affecting treatment outcome. METHODS: We retrospectively reviewed 51 adult patients with a diagnosis of tuberculous arthritis at Chang Gung Memorial Hospital-Linkou over a 14-year period. RESULTS: There were 35 males and 16 females with a mean age of 58.9 years (range, 32 to 89 years). The mean duration of symptoms and signs before diagnosis was 25.4 months (range, 0.25 to 180 months). Joint pain (96.1%) and swelling (90.2%) were two major presentations. Forty five (88.2%) patients had monoarthritis. Knee (26.7%) was the most frequently involved one. Twenty six (51.0%) patients had roentgenologic evidence of pulmonary tuberculosis (TB). Forty three patients (84.3%) had positive TB culture of synovial fluid and/or tissue. Of which, 27 (63%) had positive acid-fast bacillus smear. Twenty five patients had sputum for mycobacterial smear and culture, and 17 of them had positive TB culture. Thirty six patients received post-treatment follow-up for 3 to 110 months. Among them, 8 had relapses and 28 had treatment success. Compared the relapse to the success, the former had a higher ratio of drug resistant strains (odds ratio, 7.8; 95% confidence interval, 1.025-59.337; p=0.047) and had a longer treatment duration (22.0 +/- 4.4 vs 13.2 +/- 4.1 months; p=0.001). CONCLUSIONS: Tuberculous arthritis often occurred in elderly people with male predominance. Drug resistant strain may cause a relapse of tuberculous arthritis, which may result in longer treatment duration. Routine chest X-ray and sputum for mycobacterial smear and culture could be necessary to find concurrent pulmonary TB. |
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Authors:
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Tsung-Yu Huang; Ting-Shu Wu; Chien-Chang Yang; Ping-Cherng Chiang; Kuang-Hui Yu; Ming-Hsun Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi Volume: 40 ISSN: 1684-1182 ISO Abbreviation: J Microbiol Immunol Infect Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-18 Completed Date: 2008-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956211 Medline TA: J Microbiol Immunol Infect Country: China |
Other Details:
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Languages: eng Pagination: 493-9 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Arthritis, Infectious / diagnosis*, epidemiology, therapy Drug Resistance, Bacterial Female Hospitals, Teaching Humans Male Middle Aged Recurrence Retrospective Studies Risk Factors Taiwan / epidemiology Treatment Outcome Tuberculosis, Osteoarticular / diagnosis*, epidemiology, therapy |
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