Document Detail


Tuberculous meningitis-related optic neuritis: recovery of vision with thalidomide in 4 consecutive cases.
MedLine Citation:
PMID:  20519667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blindness is an uncommon but devastating complication of tuberculosis meningitis. The main causes are chronically raised intracranial pressure (hydrocephalus and/or tuberculomas) or direct involvement of the optic chiasm or optic nerves by the basal arachnoiditis (inflammation and/or compression). Antituberculosis therapy combined with corticosteroids and control of intracranial pressure constitutes the mainstay of therapy for tuberculous meningitis. Despite these treatment measures, some patients develop blindness, mainly as a result of progressive optochiasmatic arachnoiditis. This led us to explore the role of adjuvant thalidomide therapy, and we describe the dramatic recovery of vision in 4 consecutive cases. Clinical recovery was accompanied by marked radiological improvement on magnetic resonance imaging (MRI) of the brain.
Authors:
Johan F Schoeman; Savvas Andronikou; D Christina Stefan; Nicola Freeman; Ronald van Toorn
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-06-02
Journal Detail:
Title:  Journal of child neurology     Volume:  25     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  822-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Child Health, Tygerberg Children's Hospital, Faculty of Health Sciences, University of Stellenbosch, Western Cape, South Africa. jfs@sun.ac.za
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MeSH Terms
Descriptor/Qualifier:
Antitubercular Agents / administration & dosage,  therapeutic use*
Brain / drug effects,  pathology
Child
Child, Preschool
Drug Therapy, Combination
Female
Humans
Magnetic Resonance Imaging
Male
Optic Neuritis / complications*,  drug therapy*,  pathology
Recovery of Function / drug effects
Thalidomide / administration & dosage,  therapeutic use*
Treatment Outcome
Tuberculosis, Meningeal / complications*,  drug therapy*,  pathology
Vision, Ocular
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 50-35-1/Thalidomide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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