Document Detail

Tuberculosis and pregnancy.
MedLine Citation:
PMID:  12628525     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: There are many myths surrounding pregnancy and tuberculosis (TB), and outcome of treatment. This prospective study was conducted at the Department of Obstetrics and Gynecology, SCB Medical College, Cuttack, India, and at the authors' private clinics from 1986 to 2001 to determine the outcome of pregnancy if TB is treated properly. METHODS: A total of 111 pregnant women diagnosed as having pulmonary and glandular TB were included in the study. They were matched for age, parity, and socioeconomic status with 51 pregnant women without TB (first control group), and 51 women with pulmonary TB but without pregnancy (second control group). The usual pregnancy management was given to the women in the study group, along with a short course of chemotherapy: either ethambutol, INH, or rifampicin and pyrazinamide for 2 months followed by INH and rifampicin for 4 months; or ethambutol, INH, and rifampicin for 2 months followed by INH and rifampicin for 7 months. Statistical analysis was done using a chi(2)-test. RESULTS: There were no statistical differences in duration of gestation, preterm labor, and other complications of pregnancy, labor, and puerperium between the pregnancy groups. There were no congenital anomalies in the babies born to the groups. Pregnancy had no effect on the course of TB as regards sputum conversion, stabilization of the disease, and non-relapse even after 2-5 years of follow-up and a further delivery in a few cases. CONCLUSIONS: If proper and adequate chemotherapy is given to pregnant women with TB, they are not a higher risk than non-pregnant women with TB. Neither the disease nor chemotherapy is threatening to mother or newborn. However, today the ominous combination of human immunodeficiency virus, TB, and pregnancy poses a new challenge.
S N Tripathy; S N Tripathy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  80     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-11     Completed Date:  2003-07-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Department of Obstetrics and Gynecology, SCB Medical College, Cuttack, India.
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MeSH Terms
Antitubercular Agents / administration & dosage*
Case-Control Studies
Drug Administration Schedule
Drug Therapy, Combination
Follow-Up Studies
Postnatal Care
Pregnancy Complications, Infectious / diagnosis*,  drug therapy*
Pregnancy Outcome*
Pregnancy, High-Risk
Prenatal Care
Prospective Studies
Reference Values
Risk Factors
Tuberculosis, Pulmonary / diagnosis*,  drug therapy*
Reg. No./Substance:
0/Antitubercular Agents

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