| Tuberculosis in human immunodeficiency virus-infected children. A family infection. | |
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MedLine Citation:
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PMID: 8094939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the epidemiologic and clinical features of infection with Mycobacterium tuberculosis in human immunodeficiency virus (HIV)-infected children and their families. PATIENTS AND CLINICAL SETTING: Sixty families of children with HIV infection, children of HIV indeterminate status, and seroreverters underwent follow-up in a comprehensive multidisciplinary program for children and families. METHODS: Infection with M tuberculosis was diagnosed based on a positive Mantoux test result or a positive culture. RESULTS: Mycobacterium tuberculosis infection was diagnosed in seven children (three infected with HIV, three seroreverters, and one uninfected sibling of an infected child) from four families (6%). All infections were detected in the period from March 1990 through January 1992. Six of seven children had a history of exposure to M tuberculosis in an HIV-infected adult (parent) who was an intravenous drug user, homeless, and/or noncompliant with the medical regimen. All HIV-infected children and one seroreverter had pulmonary tuberculosis. One child died of complications of tuberculosis and HIV infection. The M tuberculosis isolated from this child was resistant to isoniazid, rifampin, and streptomycin sulfate. CONCLUSIONS: Tuberculosis is a growing problem among inner-city children born to HIV-infected parents. Children infected with HIV in this study had symptomatic and severe disease with tuberculosis, which reflected the drug susceptibility pattern of M tuberculosis seen in our community. |
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Authors:
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S S Bakshi; D Alvarez; C L Hilfer; E M Sordillo; R Grover; R Kairam |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 147 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-03-25 Completed Date: 1993-03-25 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 320-4 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Pediatrics, Columbia University College of Physicians and Surgeons, St Luke's Roosevelt Hospital Center, New York, NY. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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blood,
epidemiology*,
radiography Adult CD4-Positive T-Lymphocytes Child Child, Preschool Drug Resistance, Microbial Family* Female Follow-Up Studies Humans Infant Male New York City / epidemiology Risk Factors Severity of Illness Index Tuberculin Test Tuberculosis, Pulmonary / blood, epidemiology*, radiography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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