Document Detail

Tuberculosis in human immunodeficiency virus-infected children. A family infection.
MedLine Citation:
PMID:  8094939     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the epidemiologic and clinical features of infection with Mycobacterium tuberculosis in human immunodeficiency virus (HIV)-infected children and their families. PATIENTS AND CLINICAL SETTING: Sixty families of children with HIV infection, children of HIV indeterminate status, and seroreverters underwent follow-up in a comprehensive multidisciplinary program for children and families. METHODS: Infection with M tuberculosis was diagnosed based on a positive Mantoux test result or a positive culture. RESULTS: Mycobacterium tuberculosis infection was diagnosed in seven children (three infected with HIV, three seroreverters, and one uninfected sibling of an infected child) from four families (6%). All infections were detected in the period from March 1990 through January 1992. Six of seven children had a history of exposure to M tuberculosis in an HIV-infected adult (parent) who was an intravenous drug user, homeless, and/or noncompliant with the medical regimen. All HIV-infected children and one seroreverter had pulmonary tuberculosis. One child died of complications of tuberculosis and HIV infection. The M tuberculosis isolated from this child was resistant to isoniazid, rifampin, and streptomycin sulfate. CONCLUSIONS: Tuberculosis is a growing problem among inner-city children born to HIV-infected parents. Children infected with HIV in this study had symptomatic and severe disease with tuberculosis, which reflected the drug susceptibility pattern of M tuberculosis seen in our community.
S S Bakshi; D Alvarez; C L Hilfer; E M Sordillo; R Grover; R Kairam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  147     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-03-25     Completed Date:  1993-03-25     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  320-4     Citation Subset:  AIM; IM; X    
Department of Pediatrics, Columbia University College of Physicians and Surgeons, St Luke's Roosevelt Hospital Center, New York, NY.
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MeSH Terms
AIDS-Related Opportunistic Infections / blood,  epidemiology*,  radiography
CD4-Positive T-Lymphocytes
Child, Preschool
Drug Resistance, Microbial
Follow-Up Studies
New York City / epidemiology
Risk Factors
Severity of Illness Index
Tuberculin Test
Tuberculosis, Pulmonary / blood,  epidemiology*,  radiography

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