Document Detail

Tuberculosis during infancy.
MedLine Citation:
PMID:  10815734     Owner:  NLM     Status:  MEDLINE    
SETTING: A worldwide re-emergence of tuberculosis has been observed during the last decade. However, few studies of infants with tuberculosis appear in the literature. OBJECTIVE: To describe tuberculosis during infancy. DESIGN: The records of all infants diagnosed with tuberculosis at a tertiary care hospital from 1982 to 1998 were reviewed. RESULTS: Thirty-nine infants with a median age of 10 months were identified, 59% of whom presented during the second half of the study period. Diagnoses included endothoracic tuberculosis (33 patients), meningitis (3), miliary tuberculosis (2) and cervical lymphadenitis (1). Reasons for medical evaluation were the onset of symptoms (25 patients), contact investigation (12) and tuberculin skin test screening (2). Common signs and symptoms included fever (22 patients), cough (7), appetite loss (4) and wheezing/rales (4). Chest X-ray revealed hilar adenopathy (22 patients), infiltrates (16), atelectases (3) and miliary pattern (2). Cultures were attempted in nine patients and were positive in seven. All patients responded promptly to treatment. No complications or deaths occurred. CONCLUSION: Tuberculosis in infants has been diagnosed increasingly during the last decade. Endothoracic tuberculosis predominates. One third of the patients were diagnosed due to contact investigation. As early diagnosis and treatment appears to prevent complications and reduce mortality, pediatricians should be alert for tuberculosis in an infant with an atypical picture suggestive of infection.
H C Maltezou; P Spyridis; D A Kafetzis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  4     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-21     Completed Date:  2000-07-21     Revised Date:  2006-06-12    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  414-9     Citation Subset:  IM    
University of Athens Second Department of Pediatrics, P. & A. Kyriakou Children's Hospital, Greece.
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MeSH Terms
Antitubercular Agents / therapeutic use
Greece / epidemiology
Hospitals, University
Infant, Newborn
Mycobacterium tuberculosis / isolation & purification
Risk Factors
Tuberculosis / diagnosis,  drug therapy,  epidemiology*
Reg. No./Substance:
0/Antitubercular Agents

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